Welcome to the Division of Chemical & Systems Biology

Sturrock Publications

  • 2017

    1. Larmuth, K. M., G. Masuyer, R. G. Douglas, S. L. Schwager, K. R. Acharya and E. D. Sturrock (2016). "Kinetic and structural characterisation of amyloid-beta peptides hydrolysis by human angiotensin-1-converting enzyme." FEBS J. 283(6):1060-76.
    2. Poglitsch M, Sturrock ED, Danser AH. (2016) Letter to the editor: Angiotensin quantification by mass spectrometry. Am J Physiol Heart Circ Physiol. 310(3):H452
    3. Sharma RK, Espinoza-Moraga M, Poblete H, Douglas RG, Sturrock ED, Caballero J, Chibale K.J Chem Inf Model.  The Dunamic Nonprime binding of sampatrilat to the C-domain of angiotensin-converting enzyme. 2016 Dec 27;56(12):2486-2494.
    4. Conrad N, Schwager SL, Carmona AK, Sturrock ED.  The effect of structural motifs on the ectodomain sheding of human angiotensin-conveting enzyme. Biochem Biophys Res Commun. 2016 Dec 2;481(1-2):111-116.
    5. Lubbe L, Sewell BT, Sturrock ED.  The influence of angiotensin converting enzyme mutations on the kinetics and dynamics of N-domain selective inhibition. FEBS J. 2016 Nov; 283(21):3941-3961.
  • 2016

  • 2015

    1. Masuyer, G., R. G. Douglas, E. D. Sturrock and K. R. Acharya (2015). "Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme." Sci Rep 5: 13742.
    2. Sharp, S., M. Poglitsch, P. Zilla, N. H. Davies and E. D. Sturrock (2015). "Pharmacodynamic effects of C-domain-specific ACE inhibitors on the renin-angiotensin system in myocardial infarcted rats." J Renin Angiotensin Aldosterone Syst 16(4): 1149-1158. -
  • 2014

    1. Burger, D., T. L. Reudelhuber, A. Mahajan, K. Chibale, E. D. Sturrock and R. M. Touyz (2014). "Effects of a domain-selective ACE inhibitor in a mouse model of chronic angiotensin II-dependent hypertension." Clin Sci (Lond) 127(1): 57-63.
    2. Danilov, S. M., M. S. Wade, S. L. Schwager, R. G. Douglas, A. B. Nesterovitch, I. A. Popova, K. D. Hogarth, N. Bhardwaj, D. E. Schwartz, E. D. Sturrock and J. G. Garcia (2014). "A novel angiotensin I-converting enzyme mutation (S333W) impairs N-domain enzymatic cleavage of the anti-fibrotic peptide, AcSDKP." PLoS One 9(2): e88001.
    3. Denti, P., S. K. Sharp, W. L. Kroger, S. L. Schwager, A. Mahajan, M. Njoroge, L. Gibhard, I. Smit, K. Chibale, L. Wiesner, E. D. Sturrock and N. H. Davies (2014). "Pharmacokinetic evaluation of lisinopril-tryptophan, a novel C-domain ACE inhibitor." Eur J Pharm Sci 56: 113-119.
    4. Douglas, R. G., R. K. Sharma, G. Masuyer, L. Lubbe, I. Zamora, K. R. Acharya, K. Chibale and E. D. Sturrock (2014). "Fragment-based design for the development of N-domain-selective angiotensin-1-converting enzyme inhibitors." Clin Sci (Lond) 126(4): 305-313.
    5. Kramer, G. J., A. Mohd, S. L. Schwager, G. Masuyer, K. R. Acharya, E. D. Sturrock and B. O. Bachmann (2014). "Interkingdom pharmacology of Angiotensin-I converting enzyme inhibitor phosphonates produced by actinomycetes." ACS Med Chem Lett 5(4): 346-351.
    6. Masuyer, G., M. Akif, B. Czarny, F. Beau, S. L. Schwager, E. D. Sturrock, R. E. Isaac, V. Dive and K. R. Acharya (2014). "Crystal structures of highly specific phosphinic tripeptide enantiomers in complex with the angiotensin-I converting enzyme." FEBS J 281(3): 943-956.
    7. Masuyer, G., C. J. Yates, E. D. Sturrock and K. R. Acharya (2014). "Angiotensin-I converting enzyme (ACE): structure, biological roles, and molecular basis for chloride ion dependence." Biol Chem 395(10): 1135-1149.
    8. Yates, C. J., G. Masuyer, S. L. Schwager, M. Akif, E. D. Sturrock and K. R. Acharya (2014). "Molecular and thermodynamic mechanisms of the chloride-dependent human angiotensin-I-converting enzyme (ACE)." J Biol Chem 289(3): 1798-1814.
  • 2013

    1. Domingo R, Sturrock ED, Collins M. ACE activity and endurance performance during the South African Ironman triathlons. International Journal of Sports Medicine (2013) 34(5):402-8.
    2. Douglas RG, Ehlers MR, Sturrock ED. Antifibrotic peptide N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP): opportunities for angiotensin-converting enzyme inhibitor design. Clinical and Experimental Pharmacologyand Physiology (2013) 40(8):535-41.
    3. Ehlers MR, Abrie JA, Sturrock ED. C domain-selective inhibition of angiotensin-converting enzyme. Journal of the Renin-Angiotensin-Aldosterone System (2013) 14(2):189-92.
    4. Masuyer G, Akif M, Czarny B, Beau F, Schwager SLU, Sturrock ED, Isaac RE, Dive V, Acharya KR. Crystal structures of highly specific phosphinic tripeptide enantiomers in complex with the angiotensin-I converting enzyme. FEBS Journal (2013) Dec 24. [Epub ahead of print]
    5. Moholisa RR, Rayner BR, Patricia Owen E, Schwager SL, Stark JS, Badri M, Cupido CL, Sturrock ED. Association of B2 receptor polymorphisms and ACE activity with ACE inhibitor-induced angioedema in black and mixed-race South Africans. The Journal of Clinical Hypertension (2013) 15(6):413-419.
    6. ED, Anthony CS, Danilov SM (2013). Peptidyl-Dipeptidase A/Angiotensin I-converting enzyme. In: Handbook of Proteolytic Enzymes 2013 pp 480-494.
    7. Douglas, R.G., Ehlers, M.R., Sturrock, E.D. (2013) The Anti-Fibrotic Peptide Ac-Sdkp: Opportunities For ACE Inhibitor Design. Clin Exp Pharmacol Physiol. doi: 10.1111/1440-1681.12062.
  • 2012

    1. Bersanetti P.A., Sabatini R.A., Matos B.S., Douglas R.G., Nchinda A., Juliano M.A., Pesquero J.B., Sturrock E.D., Carmona A. (2012) Characterization of angiotensin I-converting enzyme N-domain selectivity using positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides. Biol Chem. 393, 1547-54.
    2. Akif M, Masuyer G, Bingham RJ, Sturrock ED, Elwyn Isaac R, Ravi Acharya K. (2012)  Structural Basis of Peptide Recognition by the Angiotensin-I Converting Enzyme Homologue AnCE from Drosophila melanogaster. FEBS J. 279(24):4525-34.
    3. Douglas, R.G. and Sturrock, E.D. (2012) Structure-based design of domain-selective angiotensin-converting enzyme inhibitors. In: Chibale, K., Davies-Coleman, M. and Masimirembwa, C.(Ed) Drug Discovery in Africa. Springer ISBN 978-3-642-28174-7, pages 355-377.
    4. Masuyer, G, Schwager, S.L.U., Sturrock, E.D., Isaac, R.E., and Acharya, K.R. (2012) Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides. Sci Rep. 2012;2:717. doi: 10.1038/srep00717.
    5. Domingo R., Sturrock, E.D., and Collins, M. (2012) ACE activity and endurance performance during the South African ironman triathlons. Int J Sports Med (22 Oct, Epub ahead of print)
    6. Ntsekhe, M., Matthews, K., Wolske, J., Badri, M., Wilkinson, K.A., Wilkinson, R.J., Sturrock, E.D., Mayosi, B.M. (2012) Ac-SDKP (N-acetyl-seryl-aspartyl-lysyl-proline) and Galectin-3 levels in tuberculous pericardial effusion: implications for pathogenesis and prevention of pericardial constriction. Heart 98(17): 1326-8
    7. E. D., Anthony C. S., Danilov, S.M. (2012) Peptidyl-dipeptidase A/Angiotensin I-converting enzyme, In "Handbook of Proteolytic Enzymes", 3rd ed. Editors Rawlings, N.D., Salvesen, G., ISBN: 9780123822192
    8. Anthony, C.S., Masuyer, G., Sturrock, E.D., and Acharya, K.R. (2012) Structure based drug design of angiotensin-I converting enzyme inhibitors. Curr.Med.Chem. 19, 845-855.
    9. Ehlers, M.R., Gordon, K., Schwager, S.L., and Sturrock, E.D. (2012) Shedding the load of hypertension: the proteolytic processing of angiotensin-converting enzyme. S.Afr.Med.J. 102, 461-464.
    10. Sharma, R.K., Douglas, R.G., Louw, S., Chibale, K., and Sturrock, E.D. (2012) New ketomethylene inhibitor analogues: synthesis and assessment of structural determinants for N-domain selective inhibition of angiotensin-converting enzyme. Biol.Chem. 393, 485-493.
  • 2011

    1. Akif, M., Masuyer, G., Schwager, S.L., Bhuyan, B.J., Mugesh, G., Isaac, E.R., Sturrock, E.D., Acharya, K.R. (2011) Structural characterization of angiotensin-I converting enzyme in complex with a selenium analogue of captopril. FEBS J. 278, 3644-3650
    2. Akif,  M., Schwager, S.L., Anthony, C.S., Czarny, B., Beau. F., Dive, V., Sturrock, E.D., Acharya, K.R. (2011)  Novel mechanism of inhibition of human angiotensin-I-converting enzyme (ACE) by a highly specific phosphinic tripeptide. Biochem. J.  436(1):53-9
    3. Douglas, R. G., Ehlers, M.R.E., Sturrock, E.D. (2011) Vasopeptidase inhibition – solving the cardiovascular puzzle? Drugs of the Future 36(1), 33-43
  • 2010

    1. Anthony, C.S., Corradi, H.R., Schwager, S.L.U., Redelinghuys, P., Acharya, K.R., Sturrock, E.D. (2010) The N domain of human angiotensin-I converting enzyme: the role of N-glycosylation and the crystal structure in complex with an N domain specific phosphinic inhibitor RXP407. J. Biol. Chem. 285(46), 35685-93
    2. Akif, M., Ntai, I., Sturrock, E.D., Isaac, R.E., Bachmann, B.O., Acharya, K.R. (2010) Crystal structure of a phosphonotripeptide K-26 in complex with angiotensin converting enzyme homologue (AnCE) from Drosophila melanogaster. Biochem. Biophys. Res. Commun. 398 (3), 532-536
    3. Watermeyer J.M., Kröger W.L., O'Neill H.G., Sewell B.T., Sturrock E.D. (2010) Characterization of domain-selective inhibitor binding in angiotensin-converting enzyme using a novel derivative of lisinopril. Biochem. J. 428(1), 67-74
    4. Akif, M., Georgiadis, D., Mahajan, A., Dive, V., Sturrock, E.D., Isaac, R.E., Acharya, K.R. (2010) High-Resolution Crystal Structures of Drosophila melanogaster Angiotensin-Converting Enzyme in Complex with Novel Inhibitors and Antihypertensive Drugs. J. Mol. Biol. 400, 502-517
    5. de Andrade, M.C., Affonso, R., Fernandes, F.B., Febba, A.C., da Silva, I.D., Stella, R.C., Marson, O., Jubilut, G.N., Hirata, I.Y., Carmona, A.K., Corradi, H., Acharya, K.R., Sturrock, E.D., Casarini, D.E. (2010) Spectroscopic and structural analysis of somatic and N-domain angiotensin I-converting enzyme isoforms from mesangial cells from Wistar and spontaneously hypertensive rats. Int. J. Biol. Macromol. 47(2), 238-243
    6. Dimitropoulos, N., Papakyriakou, A., Dalkas, G.A., Sturrock, E.D., and Spyroulias, G.A. (2010) A computational approach to the study of the binding mode of dual ACE/NEP inhibitors. J. Chem. Info. Model. 50(3) 388-96